123 research outputs found
Galaxy Zoo: Disentangling the Environmental Dependence of Morphology and Colour
We analyze the environmental dependence of galaxy morphology and colour with
two-point clustering statistics, using data from the Galaxy Zoo, the largest
sample of visually classified morphologies yet compiled, extracted from the
Sloan Digital Sky Survey. We present two-point correlation functions of spiral
and early-type galaxies, and we quantify the correlation between morphology and
environment with marked correlation functions. These yield clear and precise
environmental trends across a wide range of scales, analogous to similar
measurements with galaxy colours, indicating that the Galaxy Zoo
classifications themselves are very precise. We measure morphology marked
correlation functions at fixed colour and find that they are relatively weak,
with the only residual correlation being that of red galaxies at small scales,
indicating a morphology gradient within haloes for red galaxies. At fixed
morphology, we find that the environmental dependence of colour remains strong,
and these correlations remain for fixed morphology \textit{and} luminosity. An
implication of this is that much of the morphology--density relation is due to
the relation between colour and density. Our results also have implications for
galaxy evolution: the morphological transformation of galaxies is usually
accompanied by a colour transformation, but not necessarily vice versa. A
spiral galaxy may move onto the red sequence of the colour-magnitude diagram
without quickly becoming an early-type. We analyze the significant population
of red spiral galaxies, and present evidence that they tend to be located in
moderately dense environments and are often satellite galaxies in the outskirts
of haloes. Finally, we combine our results to argue that central and satellite
galaxies tend to follow different evolutionary paths.Comment: 19 pages, 18 figures. Accepted for publication in MNRA
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity
High-grade serous ovarian carcinoma is characterised by TP53 mutation and extensive chromosome instability (CIN). Because our understanding of CIN mechanisms is based largely on analysing established cell lines, we developed a workflow for generating ex vivo cultures from patient biopsies to provide models that support interrogation of CIN mechanisms in cells not extensively cultured in vitro. Here, we describe a “living biobank” of ovarian cancer models with extensive replicative capacity, derived from both ascites and solid biopsies. Fifteen models are characterised by p53 profiling, exome sequencing and transcriptomics, and karyotyped using single-cell whole-genome sequencing. Time-lapse microscopy reveals catastrophic and highly heterogeneous mitoses, suggesting that analysis of established cell lines probably underestimates mitotic dysfunction in advanced human cancers. Drug profiling reveals cisplatin sensitivities consistent with patient responses, demonstrating that this workflow has potential to generate personalized avatars with advantages over current pre-clinical models and the potential to guide clinical decision making
Galaxy Zoo: Dust in Spirals
We investigate the effect of dust on spiral galaxies by measuring the
inclination-dependence of optical colours for 24,276 well-resolved SDSS
galaxies visually classified in Galaxy Zoo. We find clear trends of reddening
with inclination which imply a total extinction from face-on to edge-on of 0.7,
0.6, 0.5 and 0.4 magnitudes for the ugri passbands. We split the sample into
"bulgy" (early-type) and "disky" (late-type) spirals using the SDSS fracdeV (or
f_DeV) parameter and show that the average face-on colour of "bulgy" spirals is
redder than the average edge-on colour of "disky" spirals. This shows that the
observed optical colour of a spiral galaxy is determined almost equally by the
spiral type (via the bulge-disk ratio and stellar populations), and reddening
due to dust. We find that both luminosity and spiral type affect the total
amount of extinction, with "disky" spirals at M_r ~ -21.5 mags having the most
reddening. This decrease of reddening for the most luminous spirals has not
been observed before and may be related to their lower levels of recent star
formation. We compare our results with the latest dust attenuation models of
Tuffs et al. We find that the model reproduces the observed trends reasonably
well but overpredicts the amount of u-band attenuation in edge-on galaxies. We
end by discussing the effects of dust on large galaxy surveys and emphasize
that these effects will become important as we push to higher precision
measurements of galaxy properties and their clustering.Comment: MNRAS in press. 25 pages, 22 figures (including an abstract comparing
GZ classifications with common automated methods for selecting disk/early
type galaxies in SDSS data). v2 corrects typos found in proof
LEMUR: Large European Module for solar Ultraviolet Research. European contribution to JAXA's Solar-C mission
Understanding the solar outer atmosphere requires concerted, simultaneous
solar observations from the visible to the vacuum ultraviolet (VUV) and soft
X-rays, at high spatial resolution (between 0.1" and 0.3"), at high temporal
resolution (on the order of 10 s, i.e., the time scale of chromospheric
dynamics), with a wide temperature coverage (0.01 MK to 20 MK, from the
chromosphere to the flaring corona), and the capability of measuring magnetic
fields through spectropolarimetry at visible and near-infrared wavelengths.
Simultaneous spectroscopic measurements sampling the entire temperature range
are particularly important.
These requirements are fulfilled by the Japanese Solar-C mission (Plan B),
composed of a spacecraft in a geosynchronous orbit with a payload providing a
significant improvement of imaging and spectropolarimetric capabilities in the
UV, visible, and near-infrared with respect to what is available today and
foreseen in the near future.
The Large European Module for solar Ultraviolet Research (LEMUR), described
in this paper, is a large VUV telescope feeding a scientific payload of
high-resolution imaging spectrographs and cameras. LEMUR consists of two major
components: a VUV solar telescope with a 30 cm diameter mirror and a focal
length of 3.6 m, and a focal-plane package composed of VUV spectrometers
covering six carefully chosen wavelength ranges between 17 and 127 nm. The
LEMUR slit covers 280" on the Sun with 0.14" per pixel sampling. In addition,
LEMUR is capable of measuring mass flows velocities (line shifts) down to 2
km/s or better.
LEMUR has been proposed to ESA as the European contribution to the Solar C
mission.Comment: 35 pages, 14 figures. To appear on Experimental Astronom
Galaxy Zoo: Passive Red Spirals
We study the spectroscopic properties and environments of red spiral galaxies
found by the Galaxy Zoo project. By carefully selecting face-on, disk dominated
spirals we construct a sample of truly passive disks (not dust reddened, nor
dominated by old stellar populations in a bulge). As such, our red spirals
represent an interesting set of possible transition objects between normal blue
spirals and red early types. We use SDSS data to investigate the physical
processes which could have turned these objects red without disturbing their
morphology. Red spirals prefer intermediate density regimes, however there are
no obvious correlations between red spiral properties and environment -
environment alone is not sufficient to determine if a spiral will become red.
Red spirals are a small fraction of spirals at low masses, but are a
significant fraction at large stellar masses - massive galaxies are red
independent of morphology. We confirm that red spirals have older stellar popns
and less recent star formation than the main spiral population. While the
presence of spiral arms suggests that major star formation cannot have ceased
long ago, we show that these are not recent post-starbursts, so star formation
must have ceased gradually. Intriguingly, red spirals are ~4 times more likely
than normal spirals to host optically identified Seyfert or LINER, with most of
the difference coming from LINERs. We find a curiously large bar fraction in
the red spirals suggesting that the cessation of star formation and bar
instabilities are strongly correlated. We conclude by discussing the possible
origins. We suggest they may represent the very oldest spiral galaxies which
have already used up their reserves of gas - probably aided by strangulation,
and perhaps bar instabilities moving material around in the disk.Comment: MNRAS in press, 20 pages, 15 figures (v3
The Eighth Data Release of the Sloan Digital Sky Survey: First Data from SDSS-III
The Sloan Digital Sky Survey (SDSS) started a new phase in August 2008, with
new instrumentation and new surveys focused on Galactic structure and chemical
evolution, measurements of the baryon oscillation feature in the clustering of
galaxies and the quasar Ly alpha forest, and a radial velocity search for
planets around ~8000 stars. This paper describes the first data release of
SDSS-III (and the eighth counting from the beginning of the SDSS). The release
includes five-band imaging of roughly 5200 deg^2 in the Southern Galactic Cap,
bringing the total footprint of the SDSS imaging to 14,555 deg^2, or over a
third of the Celestial Sphere. All the imaging data have been reprocessed with
an improved sky-subtraction algorithm and a final, self-consistent photometric
recalibration and flat-field determination. This release also includes all data
from the second phase of the Sloan Extension for Galactic Understanding and
Evolution (SEGUE-2), consisting of spectroscopy of approximately 118,000 stars
at both high and low Galactic latitudes. All the more than half a million
stellar spectra obtained with the SDSS spectrograph have been reprocessed
through an improved stellar parameters pipeline, which has better determination
of metallicity for high metallicity stars.Comment: Astrophysical Journal Supplements, in press (minor updates from
submitted version
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Biological, clinical and population relevance of 95 loci for blood lipids.
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD
The Morphology of Galaxies in the Baryon Oscillation Spectroscopic Survey
We study the morphology of luminous and massive galaxies at 0.3<z<0.7
targeted in the Baryon Oscillation Spectroscopic Survey (BOSS) using publicly
available Hubble Space Telescope imaging from COSMOS. Our sample (240 objects)
provides a unique opportunity to check the visual morphology of these galaxies
which were targeted based solely on stellar population modelling. We find that
the majority (74+/-6%) possess an early-type morphology (elliptical or S0),
while the remainder have a late-type morphology. This is as expected from the
goals of the BOSS target selection which aimed to predominantly select slowly
evolving galaxies, for use as cosmological probes, while still obtaining a fair
fraction of actively star forming galaxies for galaxy evolution studies. We
show that a colour cut of (g-i)>2.35 selects a sub-sample of BOSS galaxies with
90% early-type morphology - more comparable to the earlier Luminous Red Galaxy
(LRG) samples of SDSS-I/II. The remaining 10% of galaxies above this cut have a
late-type morphology and may be analogous to the "passive spirals" found at
lower redshift. We find that 23+/-4% of the early-type galaxies are unresolved
multiple systems in the SDSS imaging. We estimate that at least 50% of these
are real associations (not projection effects) and may represent a significant
"dry merger" fraction. We study the SDSS pipeline sizes of BOSS galaxies which
we find to be systematically larger (by 40%) than those measured from HST
images, and provide a statistical correction for the difference. These details
of the BOSS galaxies will help users of the data fine-tune their selection
criteria, dependent on their science applications. For example, the main goal
of BOSS is to measure the cosmic distance scale and expansion rate of the
Universe to percent-level precision - a point where systematic effects due to
the details of target selection may become important.Comment: 18 pages, 11 figures; v2 as accepted by MNRA
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